Abstract 14456: Role of T1 Mapping and Extracellular Volume in Evaluating the Interstitial Matrix in Diabetic Patients With Stable Coronary Artery Disease

• Published in: Circulation (New York, N.Y.) Vol. 140; no. Suppl_1 Suppl 1; p. A14456
• Main Authors: Boros, Gustavo A, Hueb, Whady, Rezende, Paulo C, Garcia, Rosa M, Rochitte, Carlos E, Nomura, Cesar H, Dallazen, Anderson Roberto, Morais, Thamara C, Ribeiro, Matheus, Serrano, Carlos V, Ramires, Jose A, Kalil, Roberto
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 19.11.2019
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.14456

BackgroundT1 mapping is a quantitative technique of cardiac magnetic resonance (CMR) increasingly used for characterization of the myocardium. Type 2 diabetes mellitus (T2DM) may impact myocardial tissue structure, however studies that assessed this association using non-invasive methods have conflicting results.ObjectiveWe sought to compare the tissue characteristics of the non-infarcted myocardium of patients with and without diabetes with multivessel CAD.MethodsPatients with stable multivessel CAD and preserved left ventricular ejection fraction (LVEF), included in the MASS V trial, underwent contrast-enhanced CMR before revascularization procedures. Patients were stratified according to the T2DM diagnosis at baseline. Values of myocardial native T1, post-contrast T1 and extracellular volume fraction (ECV) were compared between diabetic and non-diabetic patients. Only myocardial tissue without late gadolinium enhancement were assessed.ResultsOf 155 patients studied, 67 (43%) were diabetic and 88 (57%) non-diabetic. Baseline characteristics were similiar between groups (age 70 ± 10 vs 69 ± 11; 69% vs 68% males; LVEF 65 ± 13 vs 67 ± 9). Mean Syntax score was 21.2 ± 8.5 and 20.4 ± 8.5 (p=0.52) in diabetic and non-diabetic, respectively. Myocardial native T1 values showed no diference in diabetic and non-diabetic (1013 ± 67.9 vs 1015 ± 61.4, p=0.72). However, in diabetic patients values of post-contrast T1 were significantly lower (482.2 ± 43.8 vs 499.4 ± 47.2, p=0.024) and ECV were higher (29.62 ± 6.61 vs 27.08. ± 4.22, p=0.004). Multivariable analyses adjusted for age, sex, BMI, hypertension and Syntax score showed no differences in the results.ConclusionsIn this study, T2DM was associated with higher ECV and lower post-contrast T1 values in the myocardial tissue. These findings suggest an increase in the myocardial intersticial matrix in patients with diabetes and stable multivessel CAD.