Abstract 11733: Clinical Impact of the Prognostic Nutritional Index and Body Mass Index in Survival Patients With Acute Myocardial Infarction

• Published in: Circulation (New York, N.Y.) Vol. 140; no. Suppl_1 Suppl 1; p. A11733
• Main Authors: Park, Hyun Woong, Kim, Hye Ree, Kang, Min Gyu, Kim, Kyehwan, Koh, Jin-Sin, Park, Jeong Rang, Hwang, Seok-Jae, Jeong, Young-Hoon, Ahn, Jong-Hwa, Jang, Jeong Yoon, Park, Yongwhi, Hwang, Jinyong
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 19.11.2019
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.11733

IntroductionPrognostic nutritional index (PNI) for evaluating nutritional status has been reported as a prognostic the factor for preoperative complications of gastrointestinal surgery. However, Relationship between PNI and clinical outcome in acute myocardial infarction (AMI) is not well understood.HypothesisIn this study, we assessed the associations among PNI and clinical outcome in patients with AMI undergoing percutaneous coronary intervention (PCI).MethodsPatients (n=1147, mean age, 65.6±13.1 years, 72.5% men) with AMI who underwent a percutaneous coronary intervention and albumin and lymphocyte count measurement was recruited between January 2013 and December 2015. PNI was calculated as 10 x serum albumin (g/dL) + 0.005 x total lymphocyte count (/mm3). Patients were stratified into four groups as followslow PNI (cutoff value; 50) plus low BMI (cutoff value; 23.5 kg/m2) (Group IV, n=240, 20.9%) ), low PNI plus high BMI (Group III, n=144, 12.6%), high PNI plus low BMI (Group II, n=276, 24.1%), high PNI plus high BMI (Group I, n=487, 24.5%)). Major adverse cardiovascular events (MACE) including cardiac death, re-acute myocardial infarction, revascularization, heart failure, and stroke after discharge were analyzed. The mean follow-up duration was 350 days.ResultsMACE were occurred in 123 (10.7 %). In the Kaplan-Meier analysis, Cumulated MACE was significantly elevated in Group IV and followed by Groups III, II, and IV(Figure). Multivariate Cox regression analyses showed that high PNI (hazard ratio, HR 0.58) and high BMI (HR 0.59) were independent prognostic factors for MACE. Group IV (HR 3.04) had a significantly high HR for MACE and followed group III (HR 2.04), II (HR 1.94) (reference Group I).ConclusionsOur findings indicate that PNI and BMI is a strong independent prognostic factor for MACE in patients with AMI. Additionally, the combination with PNI and BMI had an additional effect to predict for MACE.