Abstract 14544: Usefulness of Vascular Function Tests for Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A

• Published in: Circulation (New York, N.Y.) Vol. 138; no. Suppl_1 Suppl 1; p. A14544
• Main Authors: Maruhashi, Tatsuya, Higashi, Yukihito, Kajikawa, Masato, Kishimoto, Shinji, Matsui, Shogo, Hashimoto, Haruki, Takaekou, Yuji, Hidaka, Takayuki, Yusoff, Farina M, Noma, Kensuke, Tomiyama, Hirofumi, Yamashina, Akira, Takase, Bonpei, Suzuki, Toru, Kihara, Yasuki
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 06.11.2018
• ISSN: 0009-7322; 1524-4539

IntroductionThe usefulness of vascular function tests for management of patients with a history of coronary artery disease (CAD) is not fully known.MethodsWe measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with CAD for assessment of the predictive value of vascular function tests for future cardiovascular events in a prospective multicenter observational study. The primary outcome was coronary events, and the secondary outcome was a composite of coronary events, stroke, heart failure, and sudden death.ResultsDuring a median follow-up period of 49.2 months, the primary outcome occurred in 56 patients and the secondary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the primary and secondary outcomes, was significantly associated with lower risk of the primary (hazard ratio, 0.27; 95% confidence interval [CI], 0.06-0.74; P=0.008) and secondary (hazard ratio, 0.32; 95% CI, 0.09-0.79; P=0.01) outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the primary (hazard ratio, 1.86; 95% CI, 1.01-3.44; P=0.04) and secondary (hazard ratio, 2.19; 95% CI, 1.23-3.90; P=0.008) outcomes. Among four groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the primary and secondary outcomes were observed.ConclusionsIn patients with CAD, both FMD and baPWV were independent predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification.