Abstract 17275: Sex Differences in Biomarkers Predicting Severity of Coronary Artery Disease in Patients With Suspected Coronary Heart Disease: Baseline Data From the ANOX Study

• Published in: Circulation (New York, N.Y.) Vol. 134; no. Suppl_1 Suppl 1; p. A17275
• Main Authors: Wada, Hiromichi, Suzuki, Masahiro, Matsuda, Morihiro, Ajiro, Yoichi, Shinozaki, Tsuyoshi, Sakagami, Satoru, Yonezawa, Kazuya, Shimizu, Masatoshi, Funada, Junichi, Kaneko, Takeaki, Morita, Yukiko, Unoki, Takashi, Takagi, Daisuke, Ura, Shuichi, Murakami, Masataka, Iguchi, Moritake, Masunaga, Nobutoyo, Ishii, Mitsuru, Kotani, Kazuhiko, Satoh-Asahara, Noriko, Abe, Mitsuru, Akao, Masaharu, Hasegawa, Koji
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 11.11.2016
• ISSN: 0009-7322; 1524-4539

BackgroundSex differences in biomarkers predicting the presence and severity of coronary artery disease (CAD) are unclear.MethodsThe ANOX study is a multicenter, prospective cohort study to determine the predictive value of possible novel biomarkers related to angiogenesis or oxidative stress for major adverse cardiovascular events among patients undergoing elective angiography. Between January 2010 and November 2013, a total of 2,513 patients were enrolled. After excluding 93 patients who were subsequently found ineligible or withdrew consent, the baseline data of 1,625 male patients (63% with CAD, 38% with multi-vessel disease [MVD]) and 795 female patients (46% with CAD, 23% with MVD) were analyzed, respectively. Blood samples were collected from the arterial catheter sheath at the beginning of coronary angiography. The presence of angiographic CAD (≥50% stenosis in ≥ 1 coronary artery) and its severity were assessed using the Gensini score. Serum levels of vascular endothelial growth factor (VEGF), VEGF-C, soluble VEGF receptor-2, and two oxidatively modified LDLs (α1-antitrypsin/LDL and serum-amyloid-A/LDL [SAA-LDL]), as well as N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin-I (hsTrop-I), and high-sensitivity C-reactive protein, were measured.ResultsThe presence of CAD was not independently correlated with any biomarkers in men, whereas it was independently correlated with log-transformed hsTrop-I (Ln-hsTrop-I) in women. In contrast, the presence of MVD was independently correlated with Ln-NT-proBNP and Ln-SAA-LDL in men, and was independently correlated with Ln-NT-proBNP, but not with other biomarkers, in women. After excluding 233 males and 221 females with a Gensini score of 0 to obtain a normal distribution, independent determinants of the Ln-Gensini score were diabetes, LDL-cholesterol, a previous history of CAD, aspirin use, Ln-NT-proBNP, and Ln-SAA-LDL in men, and age, diabetes, a previous history of CAD, aspirin use, Ln-NT-proBNP, and Ln-hsTrop-I in women.ConclusionsThere were sex differences in biomarkers predicting the presence and severity of CAD. A high SAA-LDL value may serve as an independent predictor of the severity of CAD in male but not female patients.