Protein Aggregation on Metal Oxides Governs Catalytic Activity and Cellular Uptake (Small 34/2024)

Catalytically Active Nanomaterials Catalytically active nanomaterials offer significant potential for biomedical applications, including enhancing wound healing and inducing cancer cell death. In article number 2311115, Robert Nißler, Inge K. Herrmann, and co‐workers demonstrate that protein corona...

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Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 34
Main Authors Nißler, Robert, Dennebouy, Lena, Gogos, Alexander, Gerken, Lukas R.H., Dommke, Maximilian, Zimmermann, Monika, Pais, Michael A., Neuer, Anna L., Matter, Martin T., Kissling, Vera M., Brot, Simone, Lese, Ioana, Herrmann, Inge K.
Format Journal Article
LanguageEnglish
Published 22.08.2024
Subjects
metal oxides
nanocatalyst
nanozyme
protein corona
wound healing
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Summary:Catalytically Active Nanomaterials Catalytically active nanomaterials offer significant potential for biomedical applications, including enhancing wound healing and inducing cancer cell death. In article number 2311115, Robert Nißler, Inge K. Herrmann, and co‐workers demonstrate that protein corona formation reduces the catalytic efficacy of metal oxides and promotes their uptake by tissue‐resident macrophages. Nonetheless, endosomal conditions partially restore the nanocatalytic activity and enable access to bioactivity.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202470258