Bioluminescent Probes of Sulfatase Activity

Lighting up sulfatases: A panel of bioluminescent sulfatase reporters have been developed that can be used to investigate sulfatase activity in both human and prokaryotic cell samples. Structural modulation allowed selective probe activation by particular enzymes. This strategy has potential applica...

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 11; no. 15; pp. 2096 - 2099
Main Authors Rush, Jason S., Beatty, Kimberly E., Bertozzi, Carolyn R.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 18.10.2010
Subjects
bioluminescence
enzymes
prodrugs
proteins
sulfatases
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Summary:Lighting up sulfatases: A panel of bioluminescent sulfatase reporters have been developed that can be used to investigate sulfatase activity in both human and prokaryotic cell samples. Structural modulation allowed selective probe activation by particular enzymes. This strategy has potential application in common clinical imaging modalities, such as MRI and PET.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000115