Poly(2‐Oxazoline)

Poly(2‐oxazoline)s are water‐soluble synthetic biocompatible polymers. They are typically prepared by living cationic ring‐open polymerization. Depending on the chemical nature of the cationic initiators, two distinct polymerization mechanisms have been identified: ionic and covalent propagation. A...

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Bibliographic Details
Published inPolymers for Biomedicine pp. 31 - 50
Main Author Obeid, Rodolphe
Format Book Chapter
LanguageEnglish
Published Hoboken, NJ, USA John Wiley & Sons, Inc 13.07.2017
Subjects
functionalized poly(oxazoline)
living cationic ring opening polymerization
one‐shot block copolymerization
poly(oxazoline)
poly(oxazoline) graft
poly(oxazoline) hydrogel
stimuli responsive
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Summary:Poly(2‐oxazoline)s are water‐soluble synthetic biocompatible polymers. They are typically prepared by living cationic ring‐open polymerization. Depending on the chemical nature of the cationic initiators, two distinct polymerization mechanisms have been identified: ionic and covalent propagation. A wide variety of structural variability can be achieved by the monomer selection influencing the hydrophilicity/hydrophobicity and the living nature of the polymerization allows for the formation of block and gradient copolymers. Poly(2‐oxazoline)s are pseudopeptides and the similarity to proteins is the basis for their exceptional biocompatibility. Poly(2‐oxazoline)s started to replace poly(ethylene glycol)s in their typical fields of application, such as drug delivery, hydrogels, and surface modification.
ISBN:9781118966570
1118966570
DOI:10.1002/9781118967904.ch2