A convenient method for the preparation of tuberculostatic diacylhydrazines

1-Isonicotinoyl-2-acylhydrazines (II), which display activity against Mycobacterium tuberculosis, may be readily prepared in good yields and high purity from the reactions of isonicotinic acid hydrazide with carboxylic anhydrides in ether. The progress of the reactions can be followed opportunely by...

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Bibliographic Details
Published inBulletin des sociétés chimiques belges Vol. 106; no. 2; pp. 109 - 114
Main Authors Hearn, MJ, Kang, HJO, Thai, M
Format Journal Article
LanguageEnglish
Published GHENT Comite Van Beheer Van Het Bulletin Vzw 01.02.1997
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
HYDRAZONES
SPECTROSCOPIC PROPERTIES
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Summary:1-Isonicotinoyl-2-acylhydrazines (II), which display activity against Mycobacterium tuberculosis, may be readily prepared in good yields and high purity from the reactions of isonicotinic acid hydrazide with carboxylic anhydrides in ether. The progress of the reactions can be followed opportunely by significant changes in the mid-range infrared spectra and near-infrared spectra, permitting reliable characterization.
ISSN:0037-9646