Studies on lactams .102. Environ-friendly approaches to densely functionalized beta-lactams

A convenient approach to densely functionalized alpha-allyl-beta-lactams has been developed using organometallic reagents and alpha-keto-beta-lactams. Indium mediated Barbier reaction in aqueous media proceeded with a higher level of diastereoselectivity and chemical yield than zinc mediated Barbier...

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 5; pp. 709 - 712
Main Authors Jayaraman, M, Manhas, MS, Bose, AK
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 03.02.1997
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
AQUEOUS-MEDIA
INDIUM
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Summary:A convenient approach to densely functionalized alpha-allyl-beta-lactams has been developed using organometallic reagents and alpha-keto-beta-lactams. Indium mediated Barbier reaction in aqueous media proceeded with a higher level of diastereoselectivity and chemical yield than zinc mediated Barbier reaction in anhydrous organic solvents. (C) 1997, Elsevier Science Ltd.
ISSN:0040-4039
DOI:10.1016/S0040-4039(96)02421-5