Substituted benzimidazoles .1. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazales (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to t...

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Bibliographic Details
Published inHeterocycles Vol. 41; no. 12; pp. 2713 - 2728
Main Authors ElAbadelah, MM, Sabri, SS, Zarga, MHA, AbdelJalil, RJ
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.12.1995
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazales (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed ally significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration less than or equal to 100 mu g/ml.
ISSN:0385-5414