AN EFFICIENT SYNTHESIS OF 2-[(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL )METHOXY]-1,3-PROPANEDIYL-DI-L-VALINATE AN ANTICYTOMEGALOVIRUS AGENT

An efficient synthesis for large scale preparation of the titled compound, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1-(hydroxymethyl)ethoxyl]cytosine, 9, has been developed. The product of each step is easily purified by either distillation or recrystallization and the final product is obtaine...

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Bibliographic Details
Published inNucleosides & nucleotides Vol. 14; no. 7; pp. 1591 - 1600
Main Authors GHALI, N, JOHNSTON, AB, BEAUCHAMP, L, NASEREE, T, SCOTT, T, FLANAGAN, R, RODRIGUEZ, M
Format Journal Article
LanguageEnglish
Published NEW YORK Marcel Dekker Inc 01.01.1995
Subjects
Biochemistry & Molecular Biology
Life Sciences & Biomedicine
Science & Technology
NUCLEOSIDE SYNTHESES
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Summary:An efficient synthesis for large scale preparation of the titled compound, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1-(hydroxymethyl)ethoxyl]cytosine, 9, has been developed. The product of each step is easily purified by either distillation or recrystallization and the final product is obtained in a high overall yield.
ISSN:0732-8311
DOI:10.1080/15257779508009494