REACTION OF NORACRONYCINE AND 1-HYDROXY-3-METHOXY-10-METHYLACRIDONE WITH ALKYL-LITHIUMS AND ARYL-LITHIUMS - FORMATION OF QUINONE METHIDES

Alkyl- and aryl-lithiums reacted with noracronycine and 1-hydroxy-3-methoxy-10-methylacridone in a one-step addition-dehydration transformation to provide the corresponding 7- and 9-substituted derivatives having a quinone methide function and, therefore, potential alkylating antitumour properties.

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Bibliographic Details
Published inPerkin 1 : an international journal of organic and bio-organic chemistry no. 4; pp. 511 - 515
Main Authors JOLIVET, C, RIVALLE, C, BISAGNI, E
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.02.1995
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CYTOSTATIC ACTIVITY
ACRONYCINE
NATURAL PRODUCT CHEMISTRY
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Summary:Alkyl- and aryl-lithiums reacted with noracronycine and 1-hydroxy-3-methoxy-10-methylacridone in a one-step addition-dehydration transformation to provide the corresponding 7- and 9-substituted derivatives having a quinone methide function and, therefore, potential alkylating antitumour properties.
ISSN:1472-7781
DOI:10.1039/p19950000511