ELECTROCHEMICAL REDUCTION OF TAXOIDS - SELECTIVE PREPARATION OF 9-DIHYDRO-TAXOID, 10-DEOXY-TAXOID AND 10-DEACETOXY-TAXOID
The electrochemical reduction of docetaxel in methanol in the presence of ammonium chloride leads to 9 alpha-dihydro-docetaxel 3 and 9 beta-dihydro-docetaxel 4. Under the same conditions, the electrochemical reduction of paclitaxel gives 10-deacetoxy-paclitaxel 7. Calcium chloride as well as magnesi...
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Published in | Tetrahedron letters Vol. 35; no. 28; pp. 4999 - 5002 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
11.07.1994
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Subjects | |
Online Access | Get full text |
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Summary: | The electrochemical reduction of docetaxel in methanol in the presence of ammonium chloride leads to 9 alpha-dihydro-docetaxel 3 and 9 beta-dihydro-docetaxel 4. Under the same conditions, the electrochemical reduction of paclitaxel gives 10-deacetoxy-paclitaxel 7. Calcium chloride as well as magnesium and cerium chloride, and to some extent strontium and lithium chloride, favor IO-dehydroxylation in the docetaxel series. All these docetaxel analogs retain biological activity. |
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ISSN: | 0040-4039 |
DOI: | 10.1016/S0040-4039(00)73303-X |