5-N-ACETYLARDEEMIN, A NOVEL HETEROCYCLIC COMPOUND WHICH REVERSES MULTIPLE-DRUG RESISTANCE IN TUMOR-CELLS .2. ISOLATION AND ELUCIDATION OF THE STRUCTURE OF 5-N-ACETYLARDEEMIN AND 2 CONGENERS

A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were...

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Published inJournal of antibiotics Vol. 46; no. 3; pp. 380 - 386
Main Authors HOCHLOWSKI, JE, MULLALLY, MM, SPANTON, SG, WHITTERN, DN, HILL, P, MCALPINE, JB
Format Journal Article
LanguageEnglish
Published TOKYO JAPAN ANTIBIOT RES ASSN 01.03.1993
Subjects
Biotechnology & Applied Microbiology
Immunology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
Science & Technology
ASPERLICIN
ASPERGILLUS-ALLIACEUS
SENSITIVITY-ENHANCED DETECTION
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Summary:A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asperlicin E1).
ISSN:0021-8820
DOI:10.7164/antibiotics.46.380