SOME NEW REACTIONS OF CINNAMOYLMORPHOLINE DERIVATIVES WITH AMINO-ACIDS
Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in methanol yielded the corresponding hydrazides [19-23]. Coupling of the amino acid derivatives [2-13] with amino acid methyl ester hydrochlorides...
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| Published in | Journal of the Indian Chemical Society Vol. 69; no. 9; pp. 558 - 560 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
CALCUTTA
INDIAN CHEMICAL SOC
01.09.1992
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| Abstract | Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in methanol yielded the corresponding hydrazides [19-23]. Coupling of the amino acid derivatives [2-13] with amino acid methyl ester hydrochlorides in THF-Et3N medium using the dicyclohexylcarbodiimide method afforded the desired dipeptide methyl esters [25-30]. Some of the compounds [2-30] were found to be active against a number of microorganisms. |
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| AbstractList | Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in methanol yielded the corresponding hydrazides [19-23]. Coupling of the amino acid derivatives [2-13] with amino acid methyl ester hydrochlorides in THF-Et3N medium using the dicyclohexylcarbodiimide method afforded the desired dipeptide methyl esters [25-30]. Some of the compounds [2-30] were found to be active against a number of microorganisms. |
| Author | KHALF, NS KORA, FA ELSAYED, RA GAZZAR, MA |
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| References | KORA, FA (WOS:A1988AB17100020) 1988; 62 ELNAGGAR AM (WOS:A1992KY56100006.4) 1976; 38 ELNAGGAR, AM (WOS:A1976CR51900021) 1976; 50 ELGAMAL, MHA (WOS:A1976BT96600017) 1976; 50 ELNAGGAR, AM (WOS:A1975AB14300013) 1975; 13 ELNAGGAR, AM (WOS:A1977EF03100038) 1977; 15 ELNAGGAR AM (WOS:A1992KY56100006.13) 1986; 51 ELNAGGAR AM (WOS:A1992KY56100006.7) 1985; 38 ELNAGGAR, AM (WOS:A1976CP10500011) 1976; 14 WALTER R (WOS:A1992KY56100006.25) 1956; 89 WALTER (WOS:A1992KY56100006.23) 1955; 88 ELNAGGAR, AM (WOS:A1976BN96700023) 1976; 50 Vincent, JG (WOS:000202408400005) 1944; 55 CREMLYN, RJ (WOS:A1986C269400033) 1986; 25 ISMAIL IM (WOS:A1992KY56100006.20) 1978; 52 ELNAGGAR, AM (WOS:A1976CN96500010) 1976; 89 ELNAGGAR, AM (WOS:A1976BX03000002) 1976; 26 IRVING GW (WOS:A1992KY56100006.19) 1946; 52 ELNAGGAR, AM (WOS:A1977EF03100028) 1977; 15 EPSTEIN JA (WOS:A1992KY56100006.18) 1944; 29 ELNAGGAR, AM (WOS:A1977EE75600019) 1977; 31 ZAHER MR (WOS:A1992KY56100006.26) 1986; 41 ELNAGGAR, AM (WOS:A1978EZ06200023) 1978; 52 ELNAGGAR, AM (WOS:A1977DD67200022) 1977; 51 WALTER R (WOS:A1992KY56100006.24) 1953; 86 CARLSON, HJ (WOS:A1948UK03700004) 1948; 55 |
| References_xml | – volume: 51 start-page: 441 year: 1986 ident: WOS:A1992KY56100006.13 publication-title: J SERB CHEM SOC contributor: fullname: ELNAGGAR AM – volume: 50 start-page: 765 year: 1976 ident: WOS:A1976BT96600017 article-title: SYNTHESIS OF SOME PROTECTED AMINO-ACID AND DIPEPTIDE DERIVATIVES OF DESMETHYL-VISNAGIN publication-title: ROCZNIKI CHEMII contributor: fullname: ELGAMAL, MHA – volume: 89 start-page: 279 year: 1976 ident: WOS:A1976CN96500010 article-title: SYNTHESIS OF SOME COUMARIN AMINO ACID METHYL-ESTER DERIVATIVES publication-title: ACTA CHIMICA ACADEMIAE SCIENTARIUM HUNGARICAE contributor: fullname: ELNAGGAR, AM – volume: 14 start-page: 675 year: 1976 ident: WOS:A1976CP10500011 article-title: SYNTHESIS OF SOME N,N'-(5-ACETYLAMINOTOLUENE-2,4-DISULPHONYL)AMINO ACIDS AND N-(4-ACETYLAMINO-2-METHYLBENZENESULPHONYL)AMINO ACIDS AND THEIR DERIVATIVES publication-title: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY contributor: fullname: ELNAGGAR, AM – volume: 50 start-page: 2175 year: 1976 ident: WOS:A1976CR51900021 article-title: SYNTHESIS OF SOME 2-FUROYLAMINO, 2-THENOYLAMINO, AND 3,4,5-TRIMETHOXYBENZOYLAMINO ACID-DERIVATIVES publication-title: ROCZNIKI CHEMII contributor: fullname: ELNAGGAR, AM – volume: 29 start-page: 319 year: 1944 ident: WOS:A1992KY56100006.18 publication-title: LAB CLIN MED contributor: fullname: EPSTEIN JA – volume: 38 start-page: 287 year: 1976 ident: WOS:A1992KY56100006.4 publication-title: ACTA CHIM contributor: fullname: ELNAGGAR AM – volume: 50 start-page: 347 year: 1976 ident: WOS:A1976BN96700023 article-title: SYNTHESIS OF SOME XANTHOTOXIN-4-SULFONYLAMINO ACID METHYL-ESTER AND DIPEPTIDE DERIVATIVES publication-title: ROCZNIKI CHEMII contributor: fullname: ELNAGGAR, AM – volume: 51 start-page: 567 year: 1977 ident: WOS:A1977DD67200022 article-title: SYNTHESIS OF SOME PARA-ACETYLAMINO BENZENESULFONYLAMINO ACID-DERIVATIVES publication-title: ROCZNIKI CHEMII contributor: fullname: ELNAGGAR, AM – volume: 55 start-page: 607 year: 1948 ident: WOS:A1948UK03700004 article-title: ANTIBIOTIC SUBSTANCES SEPARATED FROM SUMAC publication-title: JOURNAL OF BACTERIOLOGY contributor: fullname: CARLSON, HJ – volume: 25 start-page: 559 year: 1986 ident: WOS:A1986C269400033 article-title: SUBSTITUTED CINNAMIDE 4-SULFONYL DERIVATIVES publication-title: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY contributor: fullname: CREMLYN, RJ – volume: 62 start-page: 749 year: 1988 ident: WOS:A1988AB17100020 article-title: SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2,3-DICHLOROQUINOXALINE-6-SULFONYLOAMINO ACID AND DIPEPTIDE DERIVATIVES publication-title: POLISH JOURNAL OF CHEMISTRY contributor: fullname: KORA, FA – volume: 26 start-page: 305 year: 1976 ident: WOS:A1976BX03000002 article-title: COPPER-COMPLEXES OF SOME TETRAPEPTIDES AND PENTAPEPTIDES CONTAINING POLYFUNCTIONAL AMINO-ACIDS publication-title: JOURNAL OF APPLIED CHEMISTRY AND BIOTECHNOLOGY contributor: fullname: ELNAGGAR, AM – volume: 55 start-page: 162 year: 1944 ident: WOS:000202408400005 article-title: Filter paper disc modification of the Oxford cup penicillin determination publication-title: PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE contributor: fullname: Vincent, JG – volume: 88 start-page: 38 year: 1955 ident: WOS:A1992KY56100006.23 publication-title: CHEM BER contributor: fullname: WALTER – volume: 86 start-page: 730 year: 1953 ident: WOS:A1992KY56100006.24 publication-title: CHEM BER contributor: fullname: WALTER R – volume: 13 start-page: 248 year: 1975 ident: WOS:A1975AB14300013 article-title: SYNTHESIS OF SOME N-SALICYLSULFONYLAMINO ACID-DERIVATIVES publication-title: INDIAN JOURNAL OF CHEMISTRY contributor: fullname: ELNAGGAR, AM – volume: 15 start-page: 850 year: 1977 ident: WOS:A1977EF03100028 article-title: SYNTHESIS OF SOME 2-(N-TOSYL-AMINOACYL)AMINOPYRIDINE OR "N-PHTHALOYL-AMINOACYL)AMINOPYRIDINE AND 2-(N-TOSYL-AMINOACYL)AMINOTHIAZOLE OR N-PHTHALOYL-AMINOACYL)AMINOTHIAZOLES publication-title: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY contributor: fullname: ELNAGGAR, AM – volume: 89 start-page: 2578 year: 1956 ident: WOS:A1992KY56100006.25 publication-title: CHEM BER contributor: fullname: WALTER R – volume: 52 start-page: 637 year: 1978 ident: WOS:A1978EZ06200023 article-title: SYNTHESIS OF NITROBENZENESULFONYLAMINO AND NITROTOLUENESULFONYLAMINO ACID AND DIPEPTIDE DERIVATIVES publication-title: POLISH JOURNAL OF CHEMISTRY contributor: fullname: ELNAGGAR, AM – volume: 52 start-page: 10 year: 1946 ident: WOS:A1992KY56100006.19 publication-title: J BACTERIOL contributor: fullname: IRVING GW – volume: 15 start-page: 863 year: 1977 ident: WOS:A1977EF03100038 article-title: SYNTHESIS OF SOME PEPTIDES CONTAINING HIPPURIC ACID, UREA, THIOUREA AND 2-AMINOPYRIDINE publication-title: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY contributor: fullname: ELNAGGAR, AM – volume: 52 start-page: 1243 year: 1978 ident: WOS:A1992KY56100006.20 publication-title: POL J CHEM contributor: fullname: ISMAIL IM – volume: 38 start-page: 7 year: 1985 ident: WOS:A1992KY56100006.7 publication-title: IL FARMACO contributor: fullname: ELNAGGAR AM – volume: 41 start-page: 9 year: 1986 ident: WOS:A1992KY56100006.26 publication-title: IL FARMACO contributor: fullname: ZAHER MR – volume: 31 start-page: 127 year: 1977 ident: WOS:A1977EE75600019 article-title: SYNTHESIS OF XANTHOTOXIN-4-SULFONYLAMINO ACID, DIPEPTIDE AND TRIPEPTIDE DERIVATIVES publication-title: CHEMICKE ZVESTI contributor: fullname: ELNAGGAR, AM |
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| Snippet | Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in... |
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| SubjectTerms | Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology |
| Title | SOME NEW REACTIONS OF CINNAMOYLMORPHOLINE DERIVATIVES WITH AMINO-ACIDS |
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