SOME NEW REACTIONS OF CINNAMOYLMORPHOLINE DERIVATIVES WITH AMINO-ACIDS

Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in methanol yielded the corresponding hydrazides [19-23]. Coupling of the amino acid derivatives [2-13] with amino acid methyl ester hydrochlorides...

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Bibliographic Details
Published inJournal of the Indian Chemical Society Vol. 69; no. 9; pp. 558 - 560
Main Authors ELSAYED, RA, KHALF, NS, GAZZAR, MA, KORA, FA
Format Journal Article
LanguageEnglish
Published CALCUTTA INDIAN CHEMICAL SOC 01.09.1992
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:Cinnamoylmorpholine-4-sulphonylamino acids [2-13] and some of the corresponding methyl esters [14-18] were prepared. Hydrazinolysis of the methyl esters in methanol yielded the corresponding hydrazides [19-23]. Coupling of the amino acid derivatives [2-13] with amino acid methyl ester hydrochlorides in THF-Et3N medium using the dicyclohexylcarbodiimide method afforded the desired dipeptide methyl esters [25-30]. Some of the compounds [2-30] were found to be active against a number of microorganisms.
ISSN:0019-4522