PNEUMOCANDINS FROM ZALERION-ARBORICOLA .1. DISCOVERY AND ISOLATION

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of...

Full description

Saved in:
Bibliographic Details
Published inJournal of antibiotics Vol. 45; no. 12; pp. 1853 - 1866
Main Authors SCHWARTZ, RE, SESIN, DF, JOSHUA, H, WILSON, KE, KEMPF, AJ, GOKLEN, KA, KUEHNER, D, GAILLIOT, P, GLEASON, C, WHITE, R, INAMINE, E, BILLS, G, SALMON, P, ZITANO, L
Format Journal Article
LanguageEnglish
Published TOKYO JAPAN ANTIBIOT RES ASSN 01.12.1992
Subjects
Biotechnology & Applied Microbiology
Immunology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
Science & Technology
ANTIFUNGAL AGENT
ACULEACIN-A
L-671,329
INVITRO
Online AccessGet full text

Cover

More Information
Summary:HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.
ISSN:0021-8820
DOI:10.7164/antibiotics.45.1853