SYNTHESIS OF APOCYNIN, A CHOLERETIC CONSTITUENT OF PICRORHIZA-KURROA AND ITS HOMOLOGS

Apocynin (4-hydroxy-3-methoxyacetophenone) and a few of its side chain homologous have been synthesized by a simple two-step procedure. The key step in the synthesis involves Grignard reaction between vanillin acetate and different haloalkanes. The carbinols thus generated have been dehydrogenated t...

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Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 26; no. 6; pp. 587 - 588
Main Authors SURI, OP, BINDRA, RS, SATTI, NK, KHAJURIA, RK
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.06.1987
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Apocynin (4-hydroxy-3-methoxyacetophenone) and a few of its side chain homologous have been synthesized by a simple two-step procedure. The key step in the synthesis involves Grignard reaction between vanillin acetate and different haloalkanes. The carbinols thus generated have been dehydrogenated to the desired compounds by stirring with DDQ in benzene. The synthesized compounds show consistent choleretic activity in experimental animals.
ISSN:0376-4699
0975-0983