A simple, highly efficient, guanidine • HCl catalysed one-pot three-component synthesis of spiro chromeno-pyrimidin- and novel spiro pyrano-pyrimidin-indolinone derivatives and their anticancer activity against Burkitt 's lymphoma CA-46 cell lines

A novel, efficient and guanidine center dot HCl catalysed synthesis of some important uracil and thiouracil-based spiro chromeno- and novel spiro pyrano-indolinones from cyclohexane/cyclopentane-1,3-diketones, malonyl ureas/ thiourea and isatins/acenapthenequinone in water under thermal condition is...

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Bibliographic Details
Published inTetrahedron Vol. 158
Main Authors Khanum, Amreen, Pasha, Mohamed Afzal
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 30.05.2024
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACID
Anticancer activity
Burkitt's lymphoma CA-46 cell lines
Spiro pyrano-indolinones
Malonyl ureas/thiourea
Water as a solvent
ADULT BURKITT
SOLVENT
DISCOVERY
SPIROOXINDOLES
Cyclohexane/cyclopentane-1,3-diones
Thermal condition
MULTICOMPONENT
MCF-7 and HeLa cell lines
Spiro chromeno-indolinones
guanidine center dot HCl
Isatins/acenapthenequinone
HETEROGENEOUS CATALYST
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Summary:A novel, efficient and guanidine center dot HCl catalysed synthesis of some important uracil and thiouracil-based spiro chromeno- and novel spiro pyrano-indolinones from cyclohexane/cyclopentane-1,3-diketones, malonyl ureas/ thiourea and isatins/acenapthenequinone in water under thermal condition is reported. The products are obtained in excellent yield within 40 min. Out of 36 test compounds, 21 were found to be very good inhibitors of Burkitt ' s Lymphoma CA -46 cell lines; and 2 of them are very powerful inhibitors. The 8 highly potent compounds which inhibited CA -46 cell lines did not show any activity towards MCF-7 and HeLa cell lines.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2024.133980