Improved synthesis of , an NIR fluorescence RGD probe targeting αvβ3 integrin

Optical imaging (OI) is gaining increasing attention in medicine as a non-invasive diagnostic imaging technology and as a useful tool for image-guided surgery. OI exploits the light emitted in the near-infrared region by fluorescent molecules able to penetrate living tissues. Cyanines are an importa...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 42; pp. 8584 - 8592
Main Authors Maschio, Rachele, Buonsanti, Federica, Crivellin, Federico, Ferretti, Fulvio, Lattuada, Luciano, Maisano, Federico, Orio, Laura, Pizzuto, Lorena, Campanella, Raphael, Clouet, Anthony, Cavallotti, Camilla, Giovenzana, Giovanni B.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.11.2023
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
REMOVAL
LIGANDS
CYANINE DYES
SPECTRAL PROPERTIES
CANCER
NEAR-INFRARED FLUORESCENCE
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Summary:Optical imaging (OI) is gaining increasing attention in medicine as a non-invasive diagnostic imaging technology and as a useful tool for image-guided surgery. OI exploits the light emitted in the near-infrared region by fluorescent molecules able to penetrate living tissues. Cyanines are an important class of fluorescent molecules and by their conjugation to peptides it is possible to achieve optical imaging of tumours by selective targeting. We report here the improvements obtained in the synthesis of DA364, a small fluorescent probe (1.5 kDa) prepared by conjugation of pentamethine cyanine Cy5.5 to an RGD peptidomimetic, which can target tumour cells overexpressing integrin alpha v beta 3 receptors.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01206a