Amplifying Reactivity of Metal Hydrides: A Heterotrimetallic NiAl2(mu(2)-H)(2) Catalyst for the Dearomatization of N-Heterocycles

Identifying methods to modulate the reactivity of metal hydrides is lacking yet highly desirable given the role they play in a plethora of catalytic applications. Herein we report novel methodology to amplify the reactivity of metal hydrides through the design of well-defined heterometallic bridged...

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Published inOrganometallics Vol. 42; no. 6; pp. 435 - 440
Main Authors De Leon, Edgardo, Gonzalez, Fernando, Bauskar, Preetika, Gonzalez-Eymard, Sergio, Santos, David De Los, Shoshani, Manar M.
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 27.03.2023
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
H BOND ACTIVATION
HYDROBORATION
HYDROGENATION
NICKEL
COMPLEXES
LIGAND
CLEAVAGE
C-H
BORYL
COBALT
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Summary:Identifying methods to modulate the reactivity of metal hydrides is lacking yet highly desirable given the role they play in a plethora of catalytic applications. Herein we report novel methodology to amplify the reactivity of metal hydrides through the design of well-defined heterometallic bridged hydride species. Catalytic hydroboration of quinolines was dramatically altered by the addition of a secondary metal to bridge the Al-hydride species LAlH. Specifically, the addition of Ni(COD)(2) led to the formation of novel heterotrimetallic species 1 which features Ni participating in 3-center bonding with sterically accessible Al-H species and exhibits catalytic hydroboration of sterically encumbered quinolines and approximately a 400 times enhancement in catalytic reactivity in comparison to LAlH.
ISSN:0276-7333
1520-6041
DOI:10.1021/acs.organomet.2c00668