Cyclic pentapeptides with anti-inflammatory, cytotoxic or ?-glucosidase inhibitory activities from Basidiobolus meristosporus

Basidiobolus meristosporus is an opportunistic pathogen of mammals with unique habitats, but its metabolites have not been extensively studied. Through semi-preparative HPLC, nine undescribed cyclic pentapeptides were isolated from mycelia of B. meristosporus RCEF4516. The structure of the compounds...

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Bibliographic Details
Published inPhytochemistry (Oxford) Vol. 209
Main Authors Zhao, Cheng, Qu, Jiaojiao, Lu, Ruili, Chen, Renjie, Dong, Quheng, Huang, Bo, Bao, Guanhu, Hu, Fenglin
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.05.2023
Subjects
Biochemistry & Molecular Biology
Life Sciences & Biomedicine
Plant Sciences
Science & Technology
glucosidase
Anti-inflammatory activity
Cytotoxicity
RANARUM
Pentapeptide
Basidiobolus meristosporus
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Summary:Basidiobolus meristosporus is an opportunistic pathogen of mammals with unique habitats, but its metabolites have not been extensively studied. Through semi-preparative HPLC, nine undescribed cyclic pentapeptides were isolated from mycelia of B. meristosporus RCEF4516. The structure of the compounds 1-9 were identified with MS/MS and NMR data and designated as basidiosin D-L respectively. The absolute configurations were determined according to the advanced Marfey's method after compound hydrolysis. Bioactivity testing showed that compounds 1, 2, 3, 4 and 8 decreased NO production in LPS-activated RAW264.7 cells in a concentrationdependent manner. The nine compounds showed cytotoxicity against RAW264.7, 293 T and HepG2 cells. All the compounds except compound 7 showed stronger inhibitory effects on alpha-glucosidase than acarbose.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2023.113636