Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp(3) C-H Functionalization

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl (E)-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attr...

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Published inJournal of organic chemistry Vol. 87; no. 1; pp. 835 - 845
Main Authors Zhang, Xiang-Jin, Wang, Zhuo, Zhang, Han, Gao, Jing-Jing, Yang, Kai-Rui, Fan, Wei-Yu, Wu, Rui-Xue, Feng, Meng-Lin, Zhu, Wei, Zhu, Yan-Ping
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 07.01.2022
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Summary:An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl (E)-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine. Scale-up experiment and the construction of natural products further prove the practicability of this strategy.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c02508