One-Pot Multicomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents

A new, facile, and environment friendly synthesis of some novel pyrazolylpyrazoline derivatives has been achieved using one-pot multicomponent reaction of substituted aromatic aldehydes, 2-acetylpyrrole or 2-acetyl-1,3-thiazole, and substituted hydrazines in the presence of sodium hydroxide in ethan...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 57; no. 10; pp. 1725 - 1732
Main Authors Zala, M. J., Vora, J. J.
Format Journal Article
LanguageEnglish
Published NEW YORK Springer Nature 01.10.2021
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
pyrazolylpyrazoline
PYRAZOLINE
antimalarial and antitubercular activity
green protocol
one-pot synthesis
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Summary:A new, facile, and environment friendly synthesis of some novel pyrazolylpyrazoline derivatives has been achieved using one-pot multicomponent reaction of substituted aromatic aldehydes, 2-acetylpyrrole or 2-acetyl-1,3-thiazole, and substituted hydrazines in the presence of sodium hydroxide in ethanol at room temperature under ultrasonication. The salient features of this green protocol are one-pot reaction, short reaction time, and straightforward workup procedure. All synthesized compounds were characterized by spectroscopic techniques, and their in vitro antitubercular and antimalarial activities were evaluated. Some of the compounds tested showed good to excellent activity compared to standard drugs.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021100225