DNA Binding and DNA Cleavage Activities of Newly Synthesized Co-II and Cu-II Complexes of a beta-Cyclodextrin Based Azo-Functionalized Schiff Base

Two water soluble complexes with Co-II and Cu-II ions were synthesized using a novel beta-cyclodextrin based azo-functionalized Schiff base as a ligand. The Schiff base and its metal complexes were characterized by different physicochemical and spectroscopic methods. From the analyses of the experim...

Full description

Saved in:
Bibliographic Details
Published inAustralian journal of chemistry Vol. 74; no. 5; pp. 341 - 350
Main Authors Das, Ananya, Mishra, Dipu Kumar, Gurung, Pritika, Dakua, Vikas Kumar, Sinha, Biswajit
Format Journal Article
LanguageEnglish
Published CLAYTON Csiro Publishing 01.01.2021
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
COPPER(II) COMPLEXES
OXIDATIVE STRESS
TRANSITION-METAL-COMPLEXES
ZN(II) COMPLEXES
LIGAND INCORPORATING AZO
CRYSTAL-STRUCTURE
ESCHERICHIA-COLI
SPECTROSCOPIC CHARACTERIZATION
SPECTRAL CHARACTERIZATION
MOLECULAR DOCKING
Online AccessGet full text

Cover

More Information
Summary:Two water soluble complexes with Co-II and Cu-II ions were synthesized using a novel beta-cyclodextrin based azo-functionalized Schiff base as a ligand. The Schiff base and its metal complexes were characterized by different physicochemical and spectroscopic methods. From the analyses of the experimental data, distorted octahedral geometry has been assigned for both the metal complexes. The binding interactions between the metal complexes andDNAwere investigated by means of a thermal denaturation study and viscosity measurements as well as by electronic absorption and fluorescence spectroscopy. The DNA cleavage efficacy of the metal complexes was also studied by agarose gel electrophoresis using pBR DNA. These studies revealed that both the metal complexes followed an intercalative mode of binding to calf thymus (CT)-DNA and also effectively cleaved the supercoiled pBR DNA. The Co-II complex, however, more efficiently cleaved CT-DNA than the Cu-II complex as much as the experimental results are concerned.
ISSN:0004-9425
1445-0038
DOI:10.1071/CH20314