Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives fromo-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction ofo-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas...

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Bibliographic Details
Published inChemistry : a European journal Vol. 26; no. 60; pp. 13738 - 13742
Main Authors Lin, Xinxin, Fang, Zheng, Zeng, Cuilian, Zhu, Chenlong, Pang, Xinyan, Liu, Chengkou, He, Wei, Duan, Jindian, Qin, Ning, Guo, Kai
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 27.10.2020
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
electrochemistry
microreactor
iso-coumarin
FLUORINATED ISOCOUMARINS
EFFICIENT SYNTHESIS
OXIDATIVE CYCLIZATION
ALKYNES
cyclization
ORGANIC ELECTROSYNTHESIS
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Summary:A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction ofo-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202001766