LITHIATION OF 1-ALKOXYINDOLE DERIVATIVES
Lithiation of 1-alkoxyindoles, 3-dimethylaminomethyl- and 3-dimethylaminoethyl-1-methoxyindole occurred regioselectively at the 2-position. The introduction of a sterically bulky group into the 2-position of 3-dimethylaminomethyl-1-methoxyindoles directed the lithiation to the 4-position.
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Published in | Heterocycles Vol. 97; no. 2; pp. 968 - 997 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
01.09.2018
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Subjects | |
Online Access | Get more information |
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Summary: | Lithiation of 1-alkoxyindoles, 3-dimethylaminomethyl- and 3-dimethylaminoethyl-1-methoxyindole occurred regioselectively at the 2-position. The introduction of a sterically bulky group into the 2-position of 3-dimethylaminomethyl-1-methoxyindoles directed the lithiation to the 4-position. |
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ISSN: | 0385-5414 1881-0942 |
DOI: | 10.3987/COM-18-S(T)77 |