Cascade reaction involving Diels-Alder cascade: modular synthesis of amino -pyrones, indolines and anilines
The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino -pyrones as Diels-Alder reaction prec...
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| Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 5; no. 24; pp. 3574 - 3578 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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21.12.2018
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| Abstract | The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino -pyrones as Diels-Alder reaction precursors, and also establish the Diels-Alder cascade for obtaining indolines and anilines. This protocol features readily available starting materials, broad substrate scope and valuable synthetic utility. |
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| AbstractList | The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino -pyrones as Diels-Alder reaction precursors, and also establish the Diels-Alder cascade for obtaining indolines and anilines. This protocol features readily available starting materials, broad substrate scope and valuable synthetic utility. |
| Author | Chen, Wei Cui, Sunliang Wang, Chaorong Shen, Yangyong |
| Author_xml | – sequence: 1 givenname: Yangyong surname: Shen fullname: Shen, Yangyong organization: Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China – sequence: 2 givenname: Chaorong surname: Wang fullname: Wang, Chaorong organization: Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China – sequence: 3 givenname: Wei surname: Chen fullname: Chen, Wei organization: Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou 310058, Zhejiang, Peoples R China – sequence: 4 givenname: Sunliang surname: Cui fullname: Cui, Sunliang email: slcui@zju.edu.cn organization: Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China |
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| Keywords | FUNCTIONALIZATION YNAMIDES ASYMMETRIC-SYNTHESIS ACIDS BROSIMONES CYCLOADDITIONS ALPHA-PYRONES 3,5-DIBROMO-2-PYRONE ALKYNES DERIVATIVES |
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| Snippet | The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its... |
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| SubjectTerms | Chemistry Chemistry, Organic Physical Sciences Science & Technology |
| Title | Cascade reaction involving Diels-Alder cascade: modular synthesis of amino -pyrones, indolines and anilines |
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