Cascade reaction involving Diels-Alder cascade: modular synthesis of amino -pyrones, indolines and anilines

The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino -pyrones as Diels-Alder reaction prec...

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Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 5; no. 24; pp. 3574 - 3578
Main Authors Shen, Yangyong, Wang, Chaorong, Chen, Wei, Cui, Sunliang
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.12.2018
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
YNAMIDES
ASYMMETRIC-SYNTHESIS
ACIDS
BROSIMONES
CYCLOADDITIONS
ALPHA-PYRONES
3,5-DIBROMO-2-PYRONE
ALKYNES
DERIVATIVES
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Summary:The Diels-Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino -pyrones as Diels-Alder reaction precursors, and also establish the Diels-Alder cascade for obtaining indolines and anilines. This protocol features readily available starting materials, broad substrate scope and valuable synthetic utility.
ISSN:2052-4129
DOI:10.1039/c8qo00939b