A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacety1-1,2,3,4-tetrahydropyridines

• Published in: Tetrahedron letters Vol. 59; no. 10; pp. 891 - 894
• Main Authors: Andrade, Valquiria P., Mittersteiner, Mateus, Lobo, Marti M., Frizzo, Clarissa P., Bonacorso, Helio G., Martins, Marcos A. P., Zanatta, Nilo
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 07.03.2018
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; Heterocycles; Tetrahydropyridin-2-arylamines; TETRAHYDROPYRIDINES; Ionic liquids; Microwave irradiation; SELECTIVE INHIBITORS; CASCADE

This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacety1-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at...