A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacety1-1,2,3,4-tetrahydropyridines

This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacety1-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at...

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Published inTetrahedron letters Vol. 59; no. 10; pp. 891 - 894
Main Authors Andrade, Valquiria P., Mittersteiner, Mateus, Lobo, Marti M., Frizzo, Clarissa P., Bonacorso, Helio G., Martins, Marcos A. P., Zanatta, Nilo
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 07.03.2018
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Heterocycles
Tetrahydropyridin-2-arylamines
TETRAHYDROPYRIDINES
Ionic liquids
Microwave irradiation
SELECTIVE INHIBITORS
CASCADE
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Summary:This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacety1-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at very good yields (87-97%), but the reaction times were very different, depending on the method used. Comparing to other methods, the time decreased to 1 min when [BMIM]BF4 under MW irradiation was used, thus evidencing a synergic effect. (C) 2018 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2018.01.059