Aminorifannycins and Sporalactams Produced in Culture by a Micromonospora sp Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics

The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-memb...

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Published inOrganic letters Vol. 19; no. 4; pp. 766 - 769
Main Authors Williams, David E., Dalisay, Doralyn S., Chen, Jessie, Polishchuck, Elena A., Patrick, Brian O., Narula, Gagandeep, Ko, Mary, Av-Gay, Yossef, Li, Haoxin, Magarvey, Nathan, Andersen, Raymond J.
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 17.02.2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
AMERICA
RESISTANCE
UPDATE
INFECTIOUS-DISEASES SOCIETY
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Summary:The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-membered ansa bridge that are both unprecedented. Sporalactam B (4) shows selective and potent inhibition of Mycobacterium tuberculosis.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b03619