Megastigmane Glycosides from Docyniaindica and Their Anti-inflammatory Activities

Using various chromatographic methods, three new megastigmane glycosides, docynicasides A-C (1-3) and ten known, (6S,9R)-vomifoliol 9-O--d-xylopyranosyl-(16)-O--d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3--l-arabinofuranoside (7), naringenin 7-O--d-glucopyranoside (8), phloridzin...

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Published inHelvetica chimica acta Vol. 99; no. 9; pp. 681 - 686
Main Authors Hoang Viet Dung, Nguyen Van Bach, Trinh Nam Trung, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Park, SeonJu, Lee, Taek Hwan, Kim, Sun Yeou, Kim, Seung Hyun
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.09.2016
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Rosaceae
Docyniaindica
Docynicasides A - C
Anti-inflammatory activities
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Summary:Using various chromatographic methods, three new megastigmane glycosides, docynicasides A-C (1-3) and ten known, (6S,9R)-vomifoliol 9-O--d-xylopyranosyl-(16)-O--d-glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3--l-arabinofuranoside (7), naringenin 7-O--d-glucopyranoside (8), phloridzin (9), phloretin 2-O--d-xylopyranosyl-(16)--d-glucopyranoside (10), pinosylvin 3-O--d-glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docyniaindica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS-stimulated BV2 cells. As the results, compounds 3-5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values ranging from 21.0 to 29.3m.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201600125