Silver-Catalyzed Direct C-sp2-H Phosphorylation of Indoles Leading to Phosphoindoles

The silver carbonate-catalyzed direct C-sp2-H phosphorylation of indoles in the presence of magnesium nitrate is described. The reaction affords selectively phosphonoindoles in moderate to good yields through a radical process. This protocol provides an efficient and general method for the preparati...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 358; no. 11; pp. 1753 - 1758
Main Authors Sun, Wang-Bin, Xue, Jian-Fei, Zhang, Guo-Yu, Zeng, Run-Sheng, An, Li-Tao, Zhang, Pei-Zhi, Zou, Jian-Ping
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 02.06.2016
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
REGIOSELECTIVE PHOSPHONATION
ROOM-TEMPERATURE
silver carbonate
C-P
ARYLATION
radical reactions
catalysis
BOND FORMATION
FUNCTIONALIZATION
indoles
HETEROARENES
PHARMACOKINETICS
FREE-RADICAL PHOSPHONYLATION
phosphorylation
DERIVATIVES
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Summary:The silver carbonate-catalyzed direct C-sp2-H phosphorylation of indoles in the presence of magnesium nitrate is described. The reaction affords selectively phosphonoindoles in moderate to good yields through a radical process. This protocol provides an efficient and general method for the preparation of 2- and 3-phosphorylated indoles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600001