Novel chemoselective F-18-radiolabeling of thiol-containing biomolecules under mild aqueous conditions
We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective F-18-labeling of thiol-containing (bio) molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clea...
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Published in | Chemical communications (Cambridge, England) Vol. 52; no. 36; pp. 6083 - 6086 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
01.01.2016
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Subjects | |
Online Access | Get full text |
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Summary: | We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective F-18-labeling of thiol-containing (bio) molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c6cc01982j |