Novel chemoselective F-18-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective F-18-labeling of thiol-containing (bio) molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clea...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 36; pp. 6083 - 6086
Main Authors Chiotellis, Aristeidis, Sladojevich, Filippo, Mu, Linjing, Herde, Adrienne Mueller, Valverde, Ibai E., Tolmachev, Vladimir, Schibli, Roger, Ametamey, Simon M., Mindt, Thomas L.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
REAGENTS
AFFIBODY MOLECULE
EXPRESSION
F-18
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Summary:We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective F-18-labeling of thiol-containing (bio) molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc01982j