PMA-SiO2-MEDIATED MCR IN PEG-400: A GREENER AZA-RIEDEL-CRAFTS REACTION LEADING TO 3-ARYLMETHYL/DIARYLMETHYL INDOLES

A greener approach for the synthesis of 3-arylmethyl/diarylmethyl indoles has been achieved via a PMA-SiO2-mediated three-component reaction (the aza-Friedel-Crafts reaction) involving indoles, aldehydes, and N,N-disubstituted anilines in PEG-400. A variety of indole derivatives were prepared by usi...

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Bibliographic Details
Published inSynthetic communications Vol. 45; no. 4; pp. 513 - 523
Main Authors Reddy, Dinne Naresh Kumar, Chandrasekhar, Kothapalli Bannoth, Ganesh, Yaddanapudi Sesha Siva, Gorantla, Srikanth Sharathchandra, Ramanjaneyulu, Siddabathuni, Kumar, K. Shiva, Pal, Manojit
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 01.01.2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MILD
MULTICOMPONENT REACTIONS
indole
ACID
PEG-400
PMA-SiO2
aniline
CATALYST
Aldehyde
MCR
EFFICIENT
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Summary:A greener approach for the synthesis of 3-arylmethyl/diarylmethyl indoles has been achieved via a PMA-SiO2-mediated three-component reaction (the aza-Friedel-Crafts reaction) involving indoles, aldehydes, and N,N-disubstituted anilines in PEG-400. A variety of indole derivatives were prepared by using this operationally simple and straightforward methodology in acceptable yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2014.966392