A facile, one-pot procedure for the formation of benzimidazoles from esters using DABAL-Me-3, an air stable source of AlMe3

A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me-3 and is compatible with a wide range of functional groups, including acid-sensitive protecting groups. (C) 2014...

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Bibliographic Details
Published inTetrahedron letters Vol. 55; no. 35; pp. 4853 - 4855
Main Authors Pinder, Joanne L., Davis, Rebecca E., Charrier, Jean-Damien
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 27.08.2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Cyclodehydration
Heterocycles
DESIGN
DABAL-Me-3
ARYL
DERIVATIVES
Benzimidizole
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Summary:A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me-3 and is compatible with a wide range of functional groups, including acid-sensitive protecting groups. (C) 2014 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2014.06.026