"Clickable" Hydrosoluble PEGylated Cryptophane as a Universal Platform for Xe-129 Magnetic Resonance Imaging Biosensors

We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of Xe-129 magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation propert...

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Bibliographic Details
Published inChemistry : a European journal Vol. 19; no. 19; pp. 6089 - 6093
Main Authors Delacour, Lea, Kotera, Naoko, Traore, Tenin, Garcia-Argote, Sebastien, Puente, Celine, Leteurtre, Francois, Gravel, Edmond, Tassali, Nawal, Boutin, Celine, Leonce, Estelle, Boulard, Yves, Berthault, Patrick, Rousseau, Bernard
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.05.2013
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
WATER-SOLUBLE CRYPTOPHANES
FUNCTIONALIZED XENON
HUMAN CARBONIC-ANHYDRASE
NMR-BASED BIOSENSORS
AZIDES
cryptophane
ENCAPSULATION
SENSITIVITY
click chemistry
TERMINAL ALKYNES
biosensors
xenon
XENON BIOSENSOR
AFFINITY
cage compounds
NMR spectroscopy
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Summary:We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of Xe-129 magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized Xe-129 MRI.
ISSN:0947-6539
DOI:10.1002/chem.201204218