"Clickable" Hydrosoluble PEGylated Cryptophane as a Universal Platform for Xe-129 Magnetic Resonance Imaging Biosensors
We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of Xe-129 magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation propert...
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Published in | Chemistry : a European journal Vol. 19; no. 19; pp. 6089 - 6093 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.05.2013
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Subjects | |
Online Access | Get full text |
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Summary: | We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of Xe-129 magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized Xe-129 MRI. |
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ISSN: | 0947-6539 |
DOI: | 10.1002/chem.201204218 |