FeNH4(SO4)(2)center dot 12H(2)O (alum)-catalyzed preparation of 1,4-dihydropyridines: improved conditions for the Hantzsch reaction

FeNH4(SO4)(2)center dot 12H(2)O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity.

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 143; no. 6; pp. 931 - 933
Main Authors Mohammadi, Ali A., Hadadzahmatkesh, Armin, Asghariganjeh, Mohammad R.
Format Journal Article
LanguageEnglish
Published WIEN Springer Nature 01.06.2012
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Multi-component reactions
FeNH4(SO4)center dot 12HO
ACID
ONE-POT SYNTHESIS
3-COMPONENT REACTION
POLYHYDROQUINOLINE DERIVATIVES
PROTOCOL
BIGINELLI
CATALYST
Hantzsch reaction
EFFICIENT
1,4-Dihydropyridines
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Summary:FeNH4(SO4)(2)center dot 12H(2)O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity.
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-011-0672-6