KAl(SO4)(2)center dot 12H(2)O (Alum) Catalyzed One-Pot Three-Component Synthesis of 2-Alkyl and 2-Aryl-4(3H)-quinazolinone under Microwave Irradiation and Solvent Free Conditions

Twenty 2,3-disubstituted-4(3H)-quinazolinones were synthesed by one-pot three-component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO4)(2)center dot 12H(2)O (Alum) under microwave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylqu...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 29; no. 9; pp. 1982 - 1984
Main Authors Mohammadi, Ali A., Hossini, Sadat S. S.
Format Journal Article
LanguageEnglish
Published MALDEN Wiley 01.09.2011
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
isatoic anhydride
SOLID-PHASE SYNTHESIS
QUINAZOLINE
orthoesters
4(3H)-quinazolinone
microwave-assisted reactions
DERIVATIVES
EFFICIENT
ammonium acetate
multi component
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Summary:Twenty 2,3-disubstituted-4(3H)-quinazolinones were synthesed by one-pot three-component method with isatoic anhydride, orthoesters and amines as raw materials in the presence of KAl(SO4)(2)center dot 12H(2)O (Alum) under microwave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquinazolin-4(3H)-one (4m), 6-bromo-2-methyl-3-phenethylquinazolin-4(3H)-one (4n) and 6-bromo-2-ethyl-3-phenethylquinazolin-4(3H)-one (4o) were characterized by IR, H-1 NMR, C-13 NMR and elemental analysis.
ISSN:1001-604X