(R)-3,5-diCF(3)-SYNPHOS and (R)-p-CF3-SYNPHOS, Electron-Poor Diphosphines for Efficient Room Temperature Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids

Two new atropisomeric electron-poor chiral diphosphine ligand analogues of SYNPHOS were prepared, and their electronic properties are described. These two ligands afforded high performance for the Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds...

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Bibliographic Details
Published inOrganic letters Vol. 13; no. 11; pp. 2806 - 2809
Main Authors Berhal, Farouk, Esseiva, Olivier, Martin, Charles-Henri, Tone, Hitoshi, Genet, Jean-Pierre, Ayad, Tahar, Ratovelomanana-Vidal, Virginie
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 03.06.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DIFLUORPHOS
PALLADIUM
KETONES
RHODIUM
HYDROGENATION
LIGANDS
COMPLEXES
ESTERS
RESOLUTION
1,4-ADDITION
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Summary:Two new atropisomeric electron-poor chiral diphosphine ligand analogues of SYNPHOS were prepared, and their electronic properties are described. These two ligands afforded high performance for the Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds at room temperature.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200495a