Efficient Palladium-Catalyzed Amination of Aryl Chlorides Using Dicyclohexylamino[(2,6-dimethyl)morpholino]phenylphosphine as a PN2 Ligand

The palladium-catalyzed amination of aryl chlorides with various amines is accomplished using dicyclohexylamino[(2,6-dimethyl)morpholino]phenylphosphine as a bulky electron-rich monoaryl phosphine ligand. The optimized reaction conditions required the use of 1 mol% each of catalyst and ligand.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 5; pp. 815 - 823
Main Authors Park, Song-Eun, Kang, Seung Beom, Jung, Kwang-Ju, Won, Ju-Eun, Lee, Sang-Gyeong, Yoon, Yong-Jin
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 02.03.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HALIDES
Buchwald-Hartwig amination
C-N
CONVERSION
COMPLEXES
BOND FORMATION
AIR
PN2 ligand
BROMIDES
IODIDES
C-N coupling
COUPLING REACTIONS
AMINES
palladium-catalyzed amination
palladium
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Summary:The palladium-catalyzed amination of aryl chlorides with various amines is accomplished using dicyclohexylamino[(2,6-dimethyl)morpholino]phenylphosphine as a bulky electron-rich monoaryl phosphine ligand. The optimized reaction conditions required the use of 1 mol% each of catalyst and ligand.
ISSN:0039-7881
DOI:10.1055/s-0028-1083337