[F-18]fluorophenyl organometallics as intermediates of no-carrier-added F-18-fluoroarylation reactions

• Published in: Journal of organometallic chemistry Vol. 692; no. 19; pp. 4084 - 4092
• Main Authors: Ermert, Johannes, Ludwig, Thomas, Gail, Rene, Coenen, Heinz H.
• Format: Journal Article
• Language: English
• Published: LAUSANNE Elsevier 01.09.2007
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Physical Sciences; Science & Technology; lodonium salts; F-18-Fluoroarylation; Organometallic compounds; I -Bromo-4-[F-18]fluorobenzene; RECEPTOR; Fluorine-18; F-18; PET

Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[F-18]fluorobenzene with high radiochemical yield, the 4[F-18]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [F-18]fluoroarene reagents with a nucleophilic reaction centre are...