[F-18]fluorophenyl organometallics as intermediates of no-carrier-added F-18-fluoroarylation reactions

Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[F-18]fluorobenzene with high radiochemical yield, the 4[F-18]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [F-18]fluoroarene reagents with a nucleophilic reaction centre are...

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Published inJournal of organometallic chemistry Vol. 692; no. 19; pp. 4084 - 4092
Main Authors Ermert, Johannes, Ludwig, Thomas, Gail, Rene, Coenen, Heinz H.
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier 01.09.2007
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
lodonium salts
F-18-Fluoroarylation
Organometallic compounds
I -Bromo-4-[F-18]fluorobenzene
RECEPTOR
Fluorine-18
F-18
PET
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Summary:Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[F-18]fluorobenzene with high radiochemical yield, the 4[F-18]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [F-18]fluoroarene reagents with a nucleophilic reaction centre are available and suitable among others for the formation of [18F]fluorophenyl compounds with electron donating substituents in the radiosynthesis of F-18-labelled complex organic structures. For these arylation reactions, however, the presence of macroscopic amounts of a haloarene as co-reactant is necessary with all n.c.a. [F-18]fluorophenyl metallics. The F-18-fluoroarylation was verified for examples of aryl-carbon, -silicon, -sulphur, and -nitrogen bond formation with radiochemical yields of 20-25% related to the starting radioactivity of [18 F]fluoride. (c) 2007 Elsevier B.V. All rights reserved.
ISSN:0022-328X
DOI:10.1016/j.jorganchem.2007.06.009