Synthesis, structure, antimicrobial, and hepatotoxic behavior of 28-and 32-membered bearing tetraamide functions and their tin(II) complexes

• Published in: Phosphorus, sulfur, and silicon and the related elements Vol. 182; no. 2; pp. 475 - 483
• Main Authors: Chauhan, Shikha, Chaudhary, Ashu, Singh, R. V.
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 01.02.2007
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Physical Sciences; Science & Technology; biomedical applications; biologically potent ligands; bivalent tin(II) complexes; hepatotoxic behavior; COBALT
• ISSN: 1042-6507
• DOI: 10.1080/10426500600977312

Tin(H) complexes of 1,8-diaminooctane and dicarboxylic acids (succinic acid and adipic acid) have been synthesized and studied. These complexes have been characterized by chemical analysis and IR, H-1 NMR, C-13 NMR, and Sn-119 NMR spectral studies, as well as X-ray powder diffraction, molecular weight determinations, and conductivity measurements An octahedral geometry around the tin atom is suggested for [Sn(MacL(n))Cl-2] complexes. The pathogenicity of certain microbial infections associated with the complexes made it obligatory to distinguish between a parent counter part and their tin(H) complexes. To make the subject interesting, biomedical applications of the complexes have been discussed.