Fluorinase mediated C-F-18 bond formation, an enzymatic tool for PET labelling

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5'-fluoro-5'-deoxyadenosine, [F-18]-5'-fluoro-5'-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 6; pp. 652 - 654
Main Authors Deng, H, Cobb, SL, Gee, AD, Lockhart, A, Martarello, L, McGlinchey, RP, O'Hagan, D, Onega, M
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.02.2006
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ACID
MECHANISM
BIOSYNTHESIS
STREPTOMYCES-CATTLEYA
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Summary:The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5'-fluoro-5'-deoxyadenosine, [F-18]-5'-fluoro-5'-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.
Bibliography:researchfish
Medline
ISSN:1359-7345
1364-548X
DOI:10.1039/b516861a