Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)(2)center dot 12H(2)O as a reusable catalyst in water and ethanol

KAI(SO4)(2)(.)l2H(2)O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as (NH4)(2)CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-d...

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 36; pp. 6123 - 6126
Main Authors Dabiri, M, Salehi, P, Otokesh, S, Baghbanzadeh, M, Kozehgary, G, Mohammadi, AA
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 05.09.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
multi-component reaction
KAl(SO4)center dot 12HO
ISOCYANIDES
4(3H)-QUINAZOLINONES
cyclocondensation
LIBRARIES
MULTICOMPONENT REACTIONS
INHIBITION
1,4-DIHYDROPYRIDINES
2,3-dihydroquinazolin-4(1H)-ones
CHEMISTRY
CYCLIZATION
reusable catalyst
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Summary:KAI(SO4)(2)(.)l2H(2)O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as (NH4)(2)CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields. (c) 2005 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2005.06.157