Synthesis of 5-hydroxy- and 5-Amino-1-tosyl-5-phenyl-3-(2-arylvinyl)-4,5dihydropyrazoles

The reaction of beta-arylacryloyloxiranes with tosylhydrazine leads to unexpected 5-hydroxysubstituted Delta(2)-pyrazolines. A series of 3-styryl substituted pyrazoles and 5-amino-Delta(2)-pyrazolines were synthesized from the 5-hydroxy-Delta(2)-pyrazolines. The mechanism of this process has been pr...

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Bibliographic Details
Published inSynlett no. 3; pp. 485 - 486
Main Authors Kuz'menok, NM, Koval'chuk, TA, Zvonok, AM
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 16.02.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
epoxy enones
PYRAZOLE DERIVATIVES
rearrangements
hydrazones
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Summary:The reaction of beta-arylacryloyloxiranes with tosylhydrazine leads to unexpected 5-hydroxysubstituted Delta(2)-pyrazolines. A series of 3-styryl substituted pyrazoles and 5-amino-Delta(2)-pyrazolines were synthesized from the 5-hydroxy-Delta(2)-pyrazolines. The mechanism of this process has been proposed based on current and previous results.
ISSN:0936-5214
1437-2096
DOI:10.1005/s-2005-862353