Synthesis of N-3,5 '-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

A novel anti-hepatitis C virus (HCV) agent, N-3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.

Saved in:
Bibliographic Details
Published inJournal of medicinal chemistry Vol. 47; no. 24; pp. 6100 - 6103
Main Authors Wang, PY, Hollecker, L, Pankiewicz, KW, Patterson, SE, Whitaker, T, McBrayer, TR, Tharnish, PM, Sidwell, RW, Stuyver, LJ, Otto, MJ, Schinazi, RF, Watanabe, KA
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 18.11.2004
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
REPLICATION
Online AccessGet full text

Cover

More Information
Summary:A novel anti-hepatitis C virus (HCV) agent, N-3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.
Bibliography:NIH RePORTER
Medline
ISSN:0022-2623
1520-4804
DOI:10.1021/jm0401210