Milbemycin alpha(17) and related compounds synthesized from milbemycin A(4): Synthetic procedure and acaricidal activities

Milbemycin alpha(17), a 14-demethyl congener of milbemycin A(4), has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin alpha(17) from milbemycin A(4), as well as our use of a similar method to prepare 24-d...

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Bibliographic Details
Published inJournal of antibiotics Vol. 56; no. 10; pp. 848 - 855
Main Authors Tsukiyama, T, Kinoshita, A, Ichinose, R, Sato, K
Format Journal Article
LanguageEnglish
Published TOKYO JAPAN ANTIBIOT RES ASSN 01.10.2003
Subjects
Biotechnology & Applied Microbiology
Immunology
Life Sciences & Biomedicine
Microbiology
Pharmacology & Pharmacy
Science & Technology
AVERMECTINS
MACROLIDE ANTIBIOTICS
FAMILY
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Summary:Milbemycin alpha(17), a 14-demethyl congener of milbemycin A(4), has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin alpha(17) from milbemycin A(4), as well as our use of a similar method to prepare 24-demethylmilbemycin A(4) from the same precursor. The acaricidal activities of these compounds were assessed against the organophosphorus-sensitive two-spotted spider mites (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
ISSN:0021-8820
DOI:10.7164/antibiotics.56.848